138588-20-2

Upstream product

• 138588-18-8 (4S,5S)-5-((1S,2S)-2-tert-Butylsulfanylcarbonyl-1-hydroxy-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 138588-17-7 ((1-(tert-butylthio)-3-methylbut-1-en-1-yl)oxy)trimethylsilane 
• 112190-41-7 (4R,5R)-4-Cyclohexylmethyl-5-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 125816-10-6 (3R,5R)-5-((R)-1-Amino-2-cyclohexyl-ethyl)-3-isopropyl-dihydro-furan-2-one 
• 138588-21-3 (4R,5R)-5-((R)-2-tert-Butylsulfanylcarbonyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A Stereoselective Synthesis of Hydroxyethylene and erythro-Dihydroxyethylene Dipeptide Isosteres: A Facial Selective anti-Aldol Reaction

A Lewis-acid catalyzed anti-aldol reaction of aldehyde 4 afforded diol 6a (95percent de).Aminolysis of the corresponding β-lactone provided erythro-dihydroxyethylene dipeptide isostere 2 while the lactone-protected hydroxyethylene dipeptide isostere 3 was obtained through selective deoxygenation and acidic deprotection. Key words: hydroxyethylene isostere; anti-aldol; aspartic proteinase; renin inhibitor; facial selective