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Usage

General Description

1,2,4-Thiadiazol-5-amine, 3-(4-methoxyphenyl)- is a chemical compound that belongs to the group of thiadiazole derivatives. It is commonly used in the pharmaceutical industry for the synthesis of various drugs due to its diverse biological activities, including anti-inflammatory, antiviral, and antifungal properties. 1,2,4-Thiadiazol-5-amine, 3-(4-methoxyphenyl)- contains a thiadiazole ring with an amino group and a 4-methoxyphenyl substituent. The 4-methoxyphenyl group is known for its ability to modulate the biological activity of the compound and enhance its pharmacological effects. Overall, 1,2,4-Thiadiazol-5-amine, 3-(4-methoxyphenyl)- is a versatile chemical that holds promise for the development of new therapeutic agents.

Upstream product

• 679411-75-7 5-chloro-3-(4'-methoxyphenyl)-1,2,4-thiadiazole 
• 51721-68-7 4-methoxybenzamidine hydrochloride 
• 874-90-8 4-methoxybenzonitrile 

Relevant academic research and scientific papers

One-Pot Synthesis of 3-Aryl-5-amino-1,2,4-thiadiazoles from Imidates and Thioureas by I2-Mediated Oxidative Construction of the N–S Bond

A simple and practical method for the one-pot synthesis of 3-aryl-5-amino-1,2,4-thiadiazoles from imidates and thioureas has been developed. The protocol proceeds through sequential base-mediated nucleophilic addition-elimination reactions and an I2-mediated oxidative coupling for the N–S bond formation. The approach employes readily available and nontoxic substrates and a simple workup to provide 3-aryl-5-amino-1,2,4-thiadiazoles that have a free or substituted amino group.

Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists

4-(4-Methoxyphenyl)-2-aminothiazole and 3-(4-methoxyphenyl)-5- aminothiadiazole derivatives have been synthesized and evaluated as selective antagonists for human adenosine A3 receptors. A methoxy group in the 4-position of the phenyl ring and