138589-45-4Relevant academic research and scientific papers
Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs
Kuroda, Tooru,Kondo, Kazuhiko,Iwasaki, Tameo,Ohtani, Akio,Takashima, Kohki
, p. 678 - 684 (2007/10/03)
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure- activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.
