138630-97-4Relevant academic research and scientific papers
Development of a Series of Phenyltetrazole Leukotriene D4(LTD4) Receptor Antagonist
Harper, Richard W.,Herron, David K.,Bollinger, Nancy G.,Sawyer, J. Scott,Baldwin, Ronald F.,et al.
, p. 1191 - 1200 (2007/10/02)
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists.A new structural series of LTD4 receptor antagonists exemplified by 5--2--2H-tetrazole was designed in which a phenyltetrazole moiety was incorporated as a receptor binding equivalent of the triene unit of LTD4.A number of these phenyltetrazoles were prepared and found to possess LTD4 receptor antagonist activity.The structure-activity relationship (SAR) of this series is described.
