1386383-66-9Relevant articles and documents
Chiral 6-NHC ligand and copper complex: Properties, application, and mechanism
Park, Jinkyoon,McQuade, D.Tyler
, p. 1485 - 1490 (2012)
We demonstrated the synthesis of chiral annulated six-membered-ring N-heterocyclic carbenes (6-NHC) and their adducts with water and alcohol. We also have shown the donating properties of chiral annulated 6-NHCs is between that of typical 5-NHCs and 6-NHCs. We have shown the synthetic conditions for 6-NHC-copper complex formation. Using the chiral 6-NHC-copper complex, we synthesized unsaturated chiral bimetallic allylic boronate reagents with high enantioselectivity. Finally, we propose a catalytic cycle that justifies observed reactivity and provides a new explanation for the role methanol has in the reaction cycle; our cycle is supported by a primary kinetic isotope effect.