6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.
1386398-83-9
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Basic information
- Product Name: 6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine
- Synonyms: 6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine
- CAS NO:1386398-83-9
- Molecular Formula:
- Molecular Weight: 278.725
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1386398-83-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine(CAS DataBase Reference)
- NIST Chemistry Reference: 6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine(1386398-83-9)
- EPA Substance Registry System: 6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine(1386398-83-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1386398-83-9(Hazardous Substances Data)
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1386398-83-9 Usage
Type
Small molecule inhibitorTarget
Tropomyosin receptor kinase (TRK) family of tyrosine kinasesTreatment
Solid tumors with NTRK gene fusionsMechanism of action
Inhibiting the TRK signaling pathwayPromising results in
Lung cancer, colorectal cancer, and sarcomasApproval
Food and Drug Administration (FDA) for use in adult and pediatric patientsClinical trials
Investigating potential use in other types of cancerCheck Digit Verification of cas no
The CAS Registry Mumber 1386398-83-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,6,3,9 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.Calculate Digit Verification of CAS Registry Number 1386398-83:
(9*1)+(8*3)+(7*8)+(6*6)+(5*3)+(4*9)+(3*8)+(2*8)+(1*3)=219
219 % 10 = 9
So 1386398-83-9 is a valid CAS Registry Number.
1386398-83-9Upstream product
1386398-83-9Downstream Products
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6-chloro-3-[2-(methylthio)-4-pyrimidinyl]-1H-Pyrazolo[3,4-d]pyrimidine
