1386405-45-3Relevant academic research and scientific papers
Synthesis, structure elucidation, DNA interaction, biological evaluation, and molecular docking of an isatin-derived tyramine bidentate Schiff base and its metal complexes
Raman, Natarajan,Sobha, Sivasangu,Mitu, Liviu
, p. 1019 - 1030 (2012)
Three new transition metal complexes [CuL2Cl2], [NiL2Cl2], and [ZnL2Cl2], where L = Schiff base derived from isatin (1H-indole-2,3-dione) and tyra-mine (4-(2-aminoethyl) phenol), have been synthesized and characterized spectroscopically. The binding properties of these complexes with calf thymus DNA have been investigated by use of electronic absorption spectroscopy, viscosity measurement, cyclic voltammetry, and molecular docking analysis. Moreover, these complexes have been found to promote the cleavage of pUC19 DNA from the supercoiled form I to the open circular form II in the presence of hydrogen peroxide. The newly synthesized compounds were screened for antibacterial activity and subjected to molecular docking studies for inhibition of the enzyme Staphylococcus aureus sortase-A, which is a novel target for antibacterials.
