138647-54-8

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 4-(2,4-dichlorophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester
• CAS NO: 138647-54-8
• Molecular Formula: C16H19Cl2NO2
• Molecular Weight: 328.238
• Mol File: 138647-54-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 4-(2,4-dichlorophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 4-(2,4-dichlorophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester(138647-54-8)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 4-(2,4-dichlorophenyl)-3,6-dihydro-, 1,1-dimethylethyl ester(138647-54-8)

Safety Data

• Hazardous Substances Data: 138647-54-8(Hazardous Substances Data)

Upstream product

• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 68716-47-2 2,4-dichlorophenylboronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1019129-73-7 C₁₁H₁₁Cl₂N 
• 756771-71-8 4-(2,4-Dichlorophenyl)-piperidine 

Relevant articles and documents

Coupling of arylboronic acids with a partially reduced pyridine derivative

tert-Butylcarbonyl 1,2,3,6-tetrahydro-4-[(trifluoromethyl)sulfonyloxy]pyridine-1-carboxyla te (2) was prepared and underwent palladium-catalyzed coupling reactions with a variety of substituted arylboronic acids 3 to produce a series of tert-butyl-4-aryl-

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

Aryl-tetrahydropyridine derivatives were prepared and their PPARα/γ dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARα/γ dual agonist with an EC50 of 1.73 and 0.64 μM in hPPARα and γ, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.