138653-54-0

Upstream product

• 6613-41-8 ethyl 3-phenylpyruvate 
• 1108741-80-5 (E)-ethyl 2-(2-(2-chlorophenyl)hydrazono)-3-phenylpropanoate 

Downstream Products

• 138653-60-8 ethyl 1-(2-cyanomethyl)-7-chloro-3-phenylindole-2-carboxylate 
• 927690-44-6 (7-chloro-3-phenyl-1H-indol-2-yl)-(2-methoxymethyl-pyrrolidin-1-yl)-methanone 
• 138653-97-1 2-carboxy-7-chloro-3-phenylindole-1-acetic acid 
• 138653-69-7 6-chloro-10-phenyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole 
• 138678-42-9 ethyl 1-(2-aminoethyl)-7-chloro-3-phenylindole-2-carboxylate 

Relevant academic research and scientific papers

Novel method for synthesis of aryl hydrazones from α-diazo esters: scope and limitations of nucleophiles

Aryl hydrazones, the precursor of Fischer indole synthesis, were easily obtained by nucleophilic addition of aryllithium reagents to diazo esters. The aryl hydrazones were converted into indoles in good yields by heating with thionyl chloride in alcohol.

3-substituted indole antiproliferative angiogenesis inhibitors

3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.