138663-21-5

Basic information

• Product Name: N-(1-azabicyclo(2.2.2)-oct-3-yl)-5-chlorospiro(benzofuran-2(3H),1'-cyclohexane)-7-carboxamide
• Synonyms: N-(1-azabicyclo(2.2.2)-oct-3-yl)-5-chlorospiro(benzofuran-2(3H),1'-cyclohexane)-7-carboxamide
• CAS NO: 138663-21-5
• Molecular Formula: C21H27 Cl N2 O2
• Molecular Weight: 0
• Mol File: 138663-21-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 500°Cat760mmHg
• Flash Point: 256.2°C
• Appearance: /
• Density: 1.29g/cm³
• CAS DataBase Reference: N-(1-azabicyclo(2.2.2)-oct-3-yl)-5-chlorospiro(benzofuran-2(3H),1'-cyclohexane)-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-azabicyclo(2.2.2)-oct-3-yl)-5-chlorospiro(benzofuran-2(3H),1'-cyclohexane)-7-carboxamide(138663-21-5)
• EPA Substance Registry System: N-(1-azabicyclo(2.2.2)-oct-3-yl)-5-chlorospiro(benzofuran-2(3H),1'-cyclohexane)-7-carboxamide(138663-21-5)

Safety Data

• Hazardous Substances Data: 138663-21-5(Hazardous Substances Data)

Upstream product

• 138572-56-2 5-chlorospiro-7-carboxylic acid 
• 138572-75-5 spiro-7-carboxylic acid 
• 138572-55-1 2-(cyclohexylidenemethyl)phenyl methoxymethyl ether 
• 138572-74-4 2-(cyclohexylidenemethyl)-1-phenol 
• 90-02-8 salicylaldehyde 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 
• 182-50-3 Spiro-(benzofuran-2(3H),1'-cyclohexan) 
• 120570-05-0 (S)-3-aminoquinuclidine 

Relevant articles and documents

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

This report describes the development of novel benzamides which are orally active, highly potent, specific antagonists of 5-HT3 receptors. Described in this first report are the structure-activity relationships that led to novel structures with improved potency and selectivity. From this series of compounds, (S)-28 was identified and selected for further evaluation as a 5- HT3 receptor antagonist. Compared with 5-HT3 antagonists such as GR 38032F, BRL 43694, and metoclopramide, (S)-28 was most active in (a) inhibiting binding to 5-HT3 receptor binding sites in rat entorhinal cortex with an K(i) value of 0.19 nM and (b) blocking cisplatin-induced emesis in the ferret with an ED50 value determined to be 9 μg/kg po.