1386977-67-8Relevant articles and documents
Efficient preparation of 2,4-diaminopyrimidine nucleosides: Total synthesis of lysidine and agmatidine
Kopina, Brett J.,Lauhon, Charles T.
, p. 4118 - 4121 (2012/10/08)
An efficient route for the synthesis of 2,4-diaminopyrimidine ribosides from cytidine is described consisting of six steps with overall yields >50% and only one chromatographic step. The key amine addition step utilizes LiCl and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to ensure clean conversion to a single tautomeric product. This route has been used to prepare the modified tRNA nucleosides lysidine and agmatidine in quantities suitable for structural characterization.