1386995-02-3Relevant academic research and scientific papers
Palladium-catalyzed amidation and amination of 8-iodopurine
Chevot, Franciane,Vabre, Roxane,Piguel, Sandrine,Legraverend, Michel
, p. 2889 - 2893 (2012)
The synthesis of 8-amido- and 8-aminopurines by a single palladium-catalyzed protocol is reported. The method proceeds efficiently and tolerates a wide range of amides and amines as coupling partners, including aryl, alkyl, sulfone, and acetal amides, as well as deactivated m- and p-nitroanilines. In this way, a library of new 6,8,9-trisubstituted purines has been synthesized. Copyright
