138714-64-4

Upstream product

• 16979-20-7 N-(4-methylbenzylidene)-4-methylaniline 
• 103-80-0 phenylacetyl chloride 
• 106-49-0 p-toluidine 
• 104-87-0 4-methyl-benzaldehyde 
• 103-82-2 phenylacetic acid 
• 33905-35-0 N-(4-methylbenzylidene)-4-methylaniline N-oxide 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

CuFe2O4nanoparticles catalyze the reaction of alkynes and nitrones for the synthesis of 2-azetidinones

CuFe2O4 nanoparticles acted as a highly efficient heterogeneous catalyst in the reaction of alkynes and nitrones (Kinugasa reaction) for the synthesis of various 2-azetidinones. In all cases, the reactions proceeded conveniently under mild conditions with good-to-excellent yields and with a wide range of functional-group tolerance. The catalyst could be separated readily using an external magnet. This journal is

Synthesis and antimicrobial activity of 1,3,4-triaryl-2-azetidinones

A set of substituted 1,3,4-triaryl-2-azetidinones were synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram- bacteria and Fungi, was tested. The compounds 23 and 30 showed remarkable activity against Pseudomonas aeruginosa.

On the azetidin-2-one ring formation. A 1H NMR investigation

Azetidin-2-ones were prepared by addition of phenylacetic acid chloride to substituted benzal-anilines in DMF. The effect of temperature and substituents at the benzal-anilines on the reaction mechanism was investigated carrying out the reaction in DMF d7 in an NMR probe of a Bruker 400-MHz spectrometer at 25 and 60°C. Proton signals, arising from two kinds of intermediates a 2-phenyl-N-(α-chlorobenzyl)-acetanilide (6) and a nitrogen-charged adduct (7) suggest that two competitive mechanisms play a role in the formation of trans and cis azetidin-2-ones.