138716-19-5

Basic information

• Product Name: 3-DIMETHYLAMINO-1-(2-FLUORO-PHENYL)-PROPENONE
• Synonyms: 3-(DIMETHYLAMINO)-1-(2-FLUOROPHENYL)-2-PROPEN-1-ONE;3-DIMETHYLAMINO-1-(2-FLUORO-PHENYL)-PROPENONE;(2E)-3-(dimethylamino)-1-(2-fluorophenyl)prop-2-en-1-one
• CAS NO: 138716-19-5
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.22
• Mol File: 138716-19-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-DIMETHYLAMINO-1-(2-FLUORO-PHENYL)-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DIMETHYLAMINO-1-(2-FLUORO-PHENYL)-PROPENONE(138716-19-5)
• EPA Substance Registry System: 3-DIMETHYLAMINO-1-(2-FLUORO-PHENYL)-PROPENONE(138716-19-5)

Safety Data

• Hazardous Substances Data: 138716-19-5(Hazardous Substances Data)

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1419184-36-3 C₂₆H₃₀FNO 
• 1419184-37-4 C₂₅H₂₈FNO 
• 1419184-27-2 C₃₉H₄₀FNOTi 
• 1380520-63-7 (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate 
• 884541-07-5 (E)-[2-((3'-N,N-dimethylamino)prop-2'-en-1'-onyl)phenyl]diphenylphosphine 

Relevant articles and documents

A new approach for the synthesis of novel naphthoquinone chalcone hybrid compounds

A facile and efficient synthesis of novel naphthoquinone-based chalcone hybrids (7 and 24) via the microwave-assisted one-pot three-component reactions of 2-substituted-1,4-naphthoquinones, N,N-dimethylformamide dimethyl acetal (DMF-DMA), and acetophenone derivatives has been reported. Whereas the synthesis of hybrids 7 proceeded via a condensation, 1,4-addition, rotation, elimination, and [1,3]-H shift sequence of steps, the synthesis of hybrids 24 were formed through a three-step sequence including condensation, 1,4-addition, and elimination reactions.

Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis

We report herein the development of a Co(III)-catalyzed enaminone-directed C-H amidation method for synthetic access to quinolones, an important heterocyclic scaffold for diverse pharmaceutically active structures. The C-H coupling with dioxazolones and subsequent deacylation of an installed amide group allow consecutive C-N coupling generation of quinolones with wide-ranging compatible substituent patterns.

Olefin polymerization behavior of titanium(IV) pyridine-2-phenolate-6- (σ-aryl) catalysts: Impact of py-adjacent and phenolate substituents

A series of Ti(IV) post-metallocene bis(benzyl) precatalysts supported by tridentate pyridine-2-phenolate-6-(σ-aryl) [O,N,C] ligands, featuring various substituents on the σ-aryl (directly adjacent to the pyridine ring: fluoro, trifluoromethyl, benzo [C4H4]) and phenolate groups (tert-butyl, trifluoromethyl, cumyl, 1,1-diphenylethyl), have been prepared. Multinuclear (including 1H, 13C, and 19F) NMR characterizations of the complexes have been performed. The principal purpose of this study was to investigate the impact of these substituents upon ethylene polymerization reactivity and polymer properties. The cumyl-phenolate σ-naphthyl Ti precatalyst, in conjunction with [Ph 3C][B(C6F5)4], displays good activity and produces polyethylene with exceptionally high MW (Mn = 4 × 106) and an Mw/Mn value (2.5) approaching single-site character at 50 C, but multisite behavior is apparent for other catalysts. DFT calculations have been performed to probe the polymerization behavior and the role of the py-adjacent substituent. These studies revealed the possibility of two distinct polymerization reactions, namely conventional and ethylene-assimilated (comprising initial ethylene insertion into the Ti-C(σ-aryl) bond) chain propagation, and found that the latter is kinetically preferred. Furthermore, the viability of another kinetically competitive pathway, namely the isomerization of the ethylene-assimilated [Ti-CH2CH2-aryl] species via β-H elimination and 2,1-reinsertion, was also indicated.