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Relevant academic research and scientific papers

Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells

A new series of diverse 1,2,3-triazole-acridinedione/xanthenedione and 1,2-isoxazole-acridinedione/xanthenedione heterocyclic hybrids have been synthesized via 1,3-dipolar coupling reaction of N/O-substituted-acridinedione-alkyne or O-substituted-xanthene

Efficient iron catalyzed ligand-free access to acridines and acridinium ions

Acridines and acridinium ions are one of the important classes of compounds in terms of their usefulness in pharmaceuticals, materials, dyes and photo-catalysis. Here we present an unconventional FeCl3-alcohol catalysed one-pot method for their

Betainium-based ionic liquids catalyzed multicomponent Hantzsch reactions for the efficient synthesis of acridinediones

In this study, a series of betainium-based ionic liquids with various anions have been synthesized and their catalytic performances for the Hantzsch reactions have been investigated. It is shown that these ionic liquids have high selectivity for the one-p

Hollow Fe3O4@DA-SO3H: an efficient and reusable heterogeneous nano-magnetic acid catalyst for synthesis of dihydropyridine and dioxodecahydroacridine derivatives

Abstract: In this work, for the first time, a highly stable and efficient super-paramagnetic catalyst, H-Fe3O4@DA-SO3H, involving hollow morphology of Fe3O4 as core and dopamine as shell was prepared

Fe3O4@SiO2-MoO3H nanoparticles: A magnetically recyclable nanocatalyst system for the synthesis of 1,8-dioxo-decahydroacridine derivatives

Molybdic acid-functionalized silica-coated nano-Fe3O4 particles (Fe3O4@SiO2-MoO3H) have been prepared as a novel heterogeneous acid catalyst using a facile process. The material was subsequ

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl aceto

Synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-diones

The reaction in a mixture of 1,3-cyclohexanedione (dimedone), arylaldehyde, and ammonium acetate at 160°C during 10–15 min in the absence of solvent leads to the formation of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones. The structure of the pr

Nano-zirconia as an excellent nano support for immobilization of sulfonic acid: A new, efficient and highly recyclable heterogeneous solid acid nanocatalyst for multicomponent reactions

Nano-zirconia-supported sulfonic acid [nano-ZrO2-SO3H (n-ZrSA)] is synthesized by immobilizing sulfonic acid groups on the surface of nano zirconium dioxide to produce a novel heterogeneous reusable solid acid nanocatalyst. This new nanocatalyst is characterized by FT-IR spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), the Hammett acidity function and pH analysis. The introduced nano-zirconia-supported sulfonic acid is used as an efficient and recyclable catalyst for different heterocyclic multicomponent reactions such as the synthesis of hexahydroquinoline, 1,8-dioxo-decahydroacridine, polyhydroquinoline and 1,8-dioxo-octahydroxanthene derivatives. Optimization of the reaction conditions was studied using a central composite design (CCD) which is one of the most widely used response surface methodologies. The newly prepared heterogeneous solid acid nanocatalyst is easily separated and reusable for five cycles without any apparent loss of its catalytic activity, which confirmed the stability of the covalent bonding of the sulfonic acid groups. n-ZrSA has advantages such as its low cost, low toxicity, ease of preparation, good stability, high reusability and operational simplicity.

TiO2-coated magnetite nanoparticle-supported sulfonic acid as a new, efficient, magnetically separable and reusable heterogeneous solid acid catalyst for multicomponent reactions

TiO2-coated magnetite nanoparticle-supported sulfonic acid (nano-Fe3O4-TiO2-SO3H (n-FTSA)) is synthesized by immobilizing -SO3H groups on the surface of nano-Fe3O4-TiO2. This catalyst can be isolated readily after completion of the reaction by an external magnetite field. The obtained results demonstrate the use of coated magnetite nanoparticles as an excellent new support for the facile recovery of sulfonic acid catalysts. The newly synthesized heterogeneous solid acid is characterized by X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FE-SEM), a vibrating sample magnetometer (VSM), FT-IR spectroscopy, thermal gravimetric analysis (TGA), Hammett acidity function and pH analysis. Significantly, the as-prepared n-FTSA exhibits a high catalytic activity for the synthesis of heterocyclic compounds such as 1,8-dioxo-decahydroacridine, 1,8-dioxo-octahydroxantene, hexahydroquinoline and polyhydroquinoline derivatives in multicomponent reactions. The magnetically separated n-FTSA can be magnetically separated and reused for several times without significant loss of activity. This confirms that the sulfonic acid groups have high stability. TiO2-coated magnetite nanoparticle-supported sulfonic acid has advantages such as low cost and toxicity, ease of preparation, magnetic separation, high stability, reusability and operational simplicity. This journal is

Alkaline earth metal catalyzed, one-pot, multi-component approach for the synthesis of dihydropyridine, acridine and xanthene derivatives in water

Ca(II) catalyzed one-pot multicomponent approach for the biologically important diverse heterocyclic compounds such as hexahydroxanthene diones, dihydropyridines and octahydroacridine diones has been described in water. Use of environmentally benign catal