138744-06-6Relevant academic research and scientific papers
Unusual reactivity of (vinylimino)phosphoranes and their utility in the preparation of pyridine and dihydropyridine derivatives
Molina, Pedro,Pastor, Aurelia,Vilaplana, Maria Jesus
, p. 8094 - 8098 (2007/10/03)
New reactions of (vinylimino)phosphoranes with aldehydes involving an initial nucleophilic attack of the β-carbon atom of the vinyl side chain on the carbonyl carbon atom are reported. Iminophosphorane 4 derived from ethyl β-azidoacrylate reacts with substituted cinnamyl aldehydes to give a mixture of 2-arylpyridine and 4-styryldihydropyridine derivatives, whereas the reaction with substituted benzaldehydes provides 4-aryldihydropyridine derivatives. However, the iminophosphorane 16 derived from the diethyl azidofumarate reacts with cinnamyl aldehydes through the expected aza-Wittig fashion to give 4-arylpyridine derivatives after dehydrogenation of the resulting dihydropyridine.
Synthesis and pharamacological screening of 1,8-dioxo-9-(substituted phenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridines
Jain, S M,Khajuria, R K,Dhar, K L,Singh, Surjeet,Bani, S,et al.
, p. 1037 - 1040 (2007/10/02)
1,8-Dioxo-9--1,2,3,4,5,6,7,8,9,10-decahydroacridines (B4-B5) and 1,8-dioxo-9-(substituted phenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridines (B6-B31) have been prepared by the condensation of substituted glucosyloxy benzaldehydes (A1-A5) and substituted benzaldehydes (A6-A31) in the presence of ammonium hydroxide using ethanol as a solvent, and their structures established by IR, PMR and mass spectral data.The compounds B1-B31 have been tested for cardiovascular, antiinflammatory, antibacterial andantiimplantation activities.
