138751-04-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-AMINO-(2-FLUORO-PHENYL)-ACETIC ACID is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to modulate various biological pathways and targets, contributing to the development of new medications with therapeutic properties.
Used in Drug Development:
(S)-AMINO-(2-FLUORO-PHENYL)-ACETIC ACID is utilized as a building block in the creation of new chemical entities with potential therapeutic applications, enhancing the discovery of innovative treatments for various diseases and conditions.
Used in Biological Research:
(S)-AMINO-(2-FLUORO-PHENYL)-ACETIC ACID serves as a valuable tool in biological research, aiding in the study of biological systems and the understanding of disease mechanisms, which is crucial for the development of new medications.

InChI:InChI=1/C8H8FNO2/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m0/s1

Upstream product

• 84145-28-8 (+/-)-2-amino-2'-fluorophenylacetic acid 
• 153327-93-6 N-Acetyl-α-(2-fluorophenyl)glycine 

Downstream Products

• 1391628-33-3 (3S,6S)-6-(2-fluorophenyl)-3-isobutyl-piperazin-2-one 
• 1391628-32-2 (3S,6S)-6-(2-fluorophenyl)-4-(5-(4-fluorophenyl)isoxazole-3-carbonyl)-3-isobutyl-piperazin-2-one 

Relevant academic research and scientific papers

Highly enantioselective titanium-catalyzed cyanation of imines at room temperature

(Figure presented) A highly active and enantioselective titanium-catalyzed cyanatlon of imines at room temperature Is described. The catalyst used Is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields In 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.

HOMOCHIRAL HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. I. PREPARATIVE BIOCATALYTIC METHOD OF OBTAINING FLUORINE-CONTAINING L- AND D-PHENYLGLYCINES

A biocatalytic method of obtaining homochiral o- and p-fluorine-substituted phenylglycines by enantiomeric hydrolysis from N-phenylacetyl or N-acetyl derivatives under the action of Escherichia coli penicillin acylase or Streptoverticillium olivoreticuli aminoacylase is proposed.The L form of the amino acid and the unhydrolyzed D-enantiomer of the initial derivative are separated by extraction and chromatographic methods.The acid hydrolysis of the D-enantiomers of N-phenylacetyl derivatives of fluorine-substituted phenylglycines leads to partial (about 15percent) racemization.With a substantially higher (by two orders of magnitude) concentration of enzyme and an increase in the reaction time it is possible to use penicillinase as a catalyst for the hydrolysis of the D-enantiomer of the N-phenylacetyl derivative not accompanied by any appreciable racemization whatever.