138751-19-6 Usage
Uses
Used in Water Treatment Industry:
Phosphonic acid, methyl-, monocyclohexyl ester, (R)is used as a stabilizer and dispersing agent for preventing scale and corrosion in water treatment processes.
Used in Metal Surface Treatment Industry:
Phosphonic acid, methyl-, monocyclohexyl ester, (R)is used as a stabilizer and dispersing agent in metal surface treatment to prevent corrosion and improve the performance of metal surfaces.
Used in Agricultural Chemicals Production:
Phosphonic acid, methyl-, monocyclohexyl ester, (R)is used as a key ingredient in the production of agricultural chemicals, contributing to the effectiveness and stability of these products.
Used in Pharmaceutical Industry:
Phosphonic acid, methyl-, monocyclohexyl ester, (R)is utilized in the pharmaceutical industry as an intermediate in the synthesis of various organic compounds, playing a crucial role in the development of new drugs and medications.
Used in Chemical Synthesis:
Phosphonic acid, methyl-, monocyclohexyl ester, (R))serves as an intermediate in the synthesis of other organic compounds, enabling the creation of a wide range of chemical products with diverse applications.
It is essential to handle and use Phosphonic acid, methyl-, monocyclohexyl ester, (R)with caution, as it may pose health and environmental risks if not managed properly.
Check Digit Verification of cas no
The CAS Registry Mumber 138751-19-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,7,5 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 138751-19:
(8*1)+(7*3)+(6*8)+(5*7)+(4*5)+(3*1)+(2*1)+(1*9)=146
146 % 10 = 6
So 138751-19-6 is a valid CAS Registry Number.
138751-19-6Relevant academic research and scientific papers
Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design
Melzer, Marco,Chen, Julian C.-H.,Heidenreich, Anne,Gaeb, Juergen,Koller, Marianne,Kehe, Kai,Blum, Marc-Michael
supporting information; experimental part, p. 17226 - 17232 (2010/03/25)
Diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris is an efficient and robust biocatalyst for the hydrolysis of a range of highly toxic organophosphorus compounds including the nerve agents sarin, soman, and cyclosarin. In contrast to the substrate diisopropyl fluorophosphate (DFP) the nerve agents possess an asymmetric phosphorus atom, which leads to pairs of enantiomers that display markedly different toxicities. Wild-type DFPase prefers the less toxic stereoisomers of the substrates which leads to slower detoxification despite rapid hydrolysis. Enzyme engineering efforts based on rational design yielded two quadruple enzyme mutants with reversed enantioselectivity and overall enhanced activity against tested nerve agents. The reversed stereochemical preference is explained through modeling studies and the crystal structures of the two mutants. Using the engineered mutants in combination with wild-type DFPase leads to significantly enhanced activity and detoxification, which is especially important for personal decontamination. Our findings may also be of relevance for the structurally related enzyme human paraoxonase (PON), which is of considerable interest as a potential catalytic in vivo scavenger in case of organophosphorus poisoning.
