138753-48-7Relevant academic research and scientific papers
SULFUR-CONTAINING HMG-COA REDUCTASE INHIBITORS
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, (2008/06/13)
Novel sulfur-containing compounds which inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, having a sulfur-containing side-chain bonded to a hydrophobic anchor group through an acetylenic or ethylenic linkage. Pharmaceutica
PHOSPHORUS-CONTAINING HMG-COA REDUCTASE INHIBITORS, NEW INTERMEDIATES AND METHOD
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, (2008/06/13)
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure STR1 wherein R is OH, or salts thereof or lower alkoxy; R. sup.x is H or alkyl;X is--CH 2--,--
Synthesis of Substituted Phenyl-, Biphenyl-, and Terphenylcarbaldehydes by Coupling of Arylpalladium Complexes with Alkyl- and Aryl-Grignard Reagents
Jendralla, Heiner
, p. 295 - 297 (2007/10/02)
Novel arylcarbaldehydes 4 (R3 = alkyl or aryl) are prepared from arylcarbaldehydes 1 via arylpalladium complexes 3.
3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 3. 7-(3,5-Disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives
Stokker, G. E.,Alberts, A. W.,Anderson, P. S.,Cragoe, E. J.,Deana, A. A.,et al.
, p. 170 - 181 (2007/10/02)
The syntheses of a series of 7-(3,5-disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactones are reported.Intrinsic 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitory activity is enhanced markedly when the biphenyl mo
