1387556-98-0Relevant articles and documents
Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol
Vijai Kumar Reddy,Prabhavathi Devi,Prasad,Poornima,Ganesh Kumar
supporting information; experimental part, p. 4678 - 4680 (2012/08/07)
We report the total synthesis of (2S,3R)-2-aminododecan-3-ol has been achieved starting from commercially available 10-undecenoic acid. The key steps involved are Sharpless asymmetric epoxidation, Miyashita's boron-directed C-2 regioselective azidolysis, generated the asymmetric centers and in situ detosylation and reduction of azido tosylate. The antifungal activity of the synthesized (2S,3R)-2-aminododecan-3-ol was evaluated on several Candida strains and was comparable to miconazole, a standard drug.