1387577-07-2Relevant academic research and scientific papers
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
Mock, Jason N.,Taliaferro, John P.,Lu, Xiao,Patel, Sravan Kumar,Cummings, Brian S.,Long, Timothy E.
, p. 4854 - 4858 (2012)
Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from l- and d-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA2β.
