138760-82-4

Upstream product

• 99113-28-7 (3S,4S)-5-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-1-pentene 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 137278-22-9 ((S)-1-Benzyl-2-oxo-but-3-enyl)-carbamic acid tert-butyl ester 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 114671-12-4 (4S,5S)-5-ethenyl-4-phenylmethyloxazolidin-2-one 
• 878441-00-0 (5S,6S)-6-benzyl-5,6-dihydro-5-diphenylphosphoryloxy-1-methylpyridin-2-one 
• 63487-02-5 6-benzyl-1-methylpyridin-2-one 
• 187531-99-3 (2R,3S)-3-benzyl-N-(2,4,6-trimethylbenzensulfonyl)-2-vinylaziridine 
• 878440-99-4 (5S,6S)-6-benzyl-5,6-dihydro-5-hydroxy-1-methylpyridin-2-one 
• 532936-17-7 (6S)-6-benzyl-3,6-dihydro-1-methylpyridin-2-one 
• 894406-92-9 (5S,6S)-5-acetoxy-6-benzyl-5,6-dihydro-1-methylpyridin-2-one 
• 879220-55-0 (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene 
• 879220-83-4 (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene 

Relevant academic research and scientific papers

Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-S N2′ reactions and their use in the preparation of low-molecule CXCR4 antagonists

Organocopper-mediated anti-SN2′ reactions of γ-phosphoryloxy-α,β-unsaturated-δ-lactams were used to prepare highly functionalized diketopiperazine mimetics. The substrate phosphates 24, 32, and 47 were prepared from a-amino acid-derived allylic

Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations

We have carefully examined the organocopper-mediated reduction-alkylation of γ-acetoxy or γ,γ-difluoro-α,β-unsaturated- δ-lactams for the synthesis of (Z)-alkene- or (E)-fluoroalkene-containing diketopiperazine mimetics. Reduction of acetates 2, 12, 14, a

Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2′ reactions

Regio- and stereoselective anti-SN2′ alkylation of γ-phosphoryloxy-α,β-unsaturated-δ-lactams with organocopper reagents allowing the preparation of N-alkylated-α,δ- substituted-β,γ-unsaturated-δ-lactams as highly functionalized diketopiperazine

A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-Vinylaziridines over Their 2,3-Trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosteres

Palladium(0)-catalyzed reactions of N-methanesulfonyl- or N-(arenesulfonyl)-3-alkyl-2-vinylaziridines reveal that 2,3-cis-isomers are more stable than the corresponding 2,3-trans-isomers in accord with ab initio calculations. A highly stereoselective synthetic route to (E)-alkene dipeptide isosteres having desired stereochemistries from 2,3-cis-3-isobutyl-2-vinylaziridine by the use of organocopper chemistry is also presented.

Design and synthesis of novel protease inhibitors. Tripeptide α′,ss′-epoxyketones as nanomolar inactivators of the proteasome

Tripeptide α′,β′-epoxyketones were prepared stereospecifically starting from Boc-[S]-phenylalanine. Diastereomer 5b inhibited the chymotrypsin-like activity of porcine endothelial cell derived proteasome at low nanomolar concentrations.

Stereoselective vinylation of amino aldehydes using 2-trimethylsilylethylidentriphenylphosphorane

2-Trimethylsilylethylidentriphenylphosphorane reacts stereoselectively with α-amino aldehydes giving the Cram chelation controlled product of vinylation of the carbonyl group. The olefinic 1,2-amino alcohols obtained with this reaction are important inter

The "benzostabase" protecting group for primary amines; application to aliphatic amines

The "benzostabase" (BSB) protecting group has been applied to primary aliphatic amines. It can be introduced via a dehydrogenative silylation employing an air- and moisture-stable reagent, and is appreciably more acid-stable than the related "stabase" group. BSB protection has been used in a stereoselective synthesis of amino-alcohols involving the addition of organometallic reagents to protected amino-aldehydes under "non-chelation control".