1387627-10-2

Upstream product

• 1387627-09-9 1-(2-chloro-10H-phenothiazin-10-yl)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)butan-2-ol 
• 92-39-7 2-chlorophenothiazine 
• 742105-63-1 2-chloro-10-((1E,3Z)-4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)buta-1,3-dien-1-yl)-10H-phenothiazine 

Downstream Products

• 1442371-77-8 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-[2-(4-methylpiperazin-1-yl)-5-oxido-10H-phenothiazin-10-yl]butan-2-ol 
• 1442371-76-7 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(2-morpholin-4-yl-5-oxido-10H-phenothiazin-10-yl)butan-2-ol 
• 1442371-94-9 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-[5-oxido-2-(4-oxidomorpholin-4-yl)-10H-phenothiazin-10-yl]butan-2-ol 
• 1442371-93-8 4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]-1-(5-oxido-10H-phenothiazin-10-yl)butan-2-ol 

Relevant academic research and scientific papers

Synthesis and pharmacological investigation of new N-hydroxyalkyl-2- aminophenothiazines exhibiting marked MDR inhibitory effect

Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration-oxidation of dienes followed by Buchwald-Hartwig cross-coupling reaction. Also, some sulfoxide and sulfone derivatives have been prepared by selective oxidations. MDR inhibition studies on rat hepatocyte cell culture revealed that some derivatives exhibit marked biological efficacy exceeding that of the standard verapamil (e.g., 3h, 4h, 16). Selected derivatives were subjected to chemical resolution to provide both enantiomers which were shown of similar activity on P-gp interaction measurements. The new compounds exhibited no toxicity.

Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators

N-dienylphenothiazines synthesized from tetrazolo[1,5-a]pyridinium salts by treatment with phenothiazine were subjected to catalytic hydrogenation to yield N-butylphenothiazines, whereas transformation of these dienes with borane dimethyl sulfide (BH3 × Me2S) resulted in selective hydroboration of one double bond and full reduction of the other double bond to give 2-hydroxybutylphenothiazines. Position of the hydroxyl group was supported by NMR spectroscopy and verified by X-ray analysis. Comparison of MDR modulatory activity of the new derivatives revealed that the hydroxybutyl compounds are promising candidates for development of novel MDR inhibitors.