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Diastereoselection in the addition of enolates to chiral α,β-epoxyaldehydes
Escudier, Jean-Marc,Baltas, Michel,Gorrichon, Liliane
, p. 5345 - 5348 (1991)
The stereochemistry of addition of lithium enolates to the α,β-epoxyaldehydes 1z-3 has been investigated. Moderate to high diastereoselectivity (up to 13:1) is obtained in favour of the anti isomer, which is explained by the Felkin-Anh model for asymmetric induction.
