138772-80-2Relevant academic research and scientific papers
Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile
Tsuji, Hiroaki,Hashimoto, Keisuke,Kawatsura, Motoi
, p. 8837 - 8841 (2019/11/11)
The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile. We have achieved the nickel-catalyzed benzylic substitution of benzyl esters with malonates as a soft carbon nucleophile. Primary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates as well as a wide variety of malonate derivatives were well tolerated in the nickel-catalyzed reaction, providing the corresponding alkylation products in 46-86% yields (34 examples). Additionally, we propose a possible reaction mechanism that would undergo via the ??1- A nd ??3-benzylnickel intermediates.
Effect of Water on Enzymatic Activity and Stereoselectivity in Organic Solvents. Transesterification of a Disubstituted Malonate Diester
Gutman, Arie L.,Shapira, Michal
, p. 1467 - 1468 (2007/10/02)
The reaction rate and stereoselectivity of the preparatively important enzymatic transesterification of a prochiral symmetrical malonate diester in organic media was shown to be considerably inreased by small quantities of added water.
