138787-11-8

Basic information

• Product Name: 7-benzyl-3-methyl-5-(beta-D-ribofuranosyl)-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3]triazin-4-one
• CAS NO: 138787-11-8
• Molecular Formula: C₁₇H₁₉N₅O₅
• Molecular Weight: 373.3633
• Mol File: 138787-11-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 682.4°C at 760 mmHg
• Flash Point: 366.5°C
• Density: 1.67g/cm³
• Vapor Pressure: 1.48E-19mmHg at 25°C
• Refractive Index: 1.768
• CAS DataBase Reference: 7-benzyl-3-methyl-5-(beta-D-ribofuranosyl)-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3]triazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyl-3-methyl-5-(beta-D-ribofuranosyl)-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3]triazin-4-one(138787-11-8)
• EPA Substance Registry System: 7-benzyl-3-methyl-5-(beta-D-ribofuranosyl)-3,5-dihydro-4H-pyrazolo[4,3-d][1,2,3]triazin-4-one(138787-11-8)

Safety Data

• Hazardous Substances Data: 138787-11-8(Hazardous Substances Data)

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 115869-70-0 3-Benzyl-7-methyl-3,5-dihydro-pyrazolo[4,3-d][1,2,3]triazin-4-one 
• 80030-79-1 5-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid benzylamide 
• 80030-85-9 4-Amino-5-methyl-2H-pyrazole-3-carboxylic acid benzylamide 
• 138787-07-2 C₃₈H₃₁N₅O₈ 

Relevant articles and documents

Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo-1,2,3-triazin-4-one Nucleosides

Several pyrazole and pyrazolo-1,2,3-triazin-4-one ribonucleosides were prepared and tested for antiviral/antitumor activities.Appropriate heterocyclic bases were prepared by standard methodologies.Glycosylation of pyrazoles 6a-e,g,i and pyrazolo-1,2,3-triazin-4-ones 12f-l mediated bu silylation with hexamethylsilazane, with 1-β-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose gave in good yields the corresponding glycosides 7a-e,g, 8g,i 13f,h,k, and 14f, but could not be applied to compounds 12g,i,j,l.To overcome this occurrence, a different strategy involvi ng the preparation, diazotization, and in situ cyclization of opportune pyrazole glycosides 9 and 10 was reguired.Moreover derivatives having the general formula 5 were considered not only as synthetic intermediates in the synthesis of 3 but also as carbon bioisosteres of ribavirin 4.All compounds were evaluated in vitro for cytostatic and antiviral activity.The pyrazolo-1,2,3-triazin-4-one nucleosides that resulted were substantially devoid of any activity; only 15h,k showed a moderate cytostatic activity against T-cells.However, pyrazole nucleosides 9b,c,e were potent and selective cytotoxic agents against T-lymphocytes, whereas 9e showed a selective, although not very potent, activity against coxsackie B1.