13879-76-0

Basic information

• Product Name: 2,2-DiMethyl-1,3-dioxolane-4-Methanol Dibenzyl Phosphate
• Synonyms: 2,2-DiMethyl-1,3-dioxolane-4-Methanol Dibenzyl Phosphate
• CAS NO: 13879-76-0
• Molecular Formula: C₂₀H₂₅O₆P
• Molecular Weight: 392.382661
• Product Categories: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 13879-76-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 165-170 °C(Press: 0.0001 Torr)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,2-DiMethyl-1,3-dioxolane-4-Methanol Dibenzyl Phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DiMethyl-1,3-dioxolane-4-Methanol Dibenzyl Phosphate(13879-76-0)
• EPA Substance Registry System: 2,2-DiMethyl-1,3-dioxolane-4-Methanol Dibenzyl Phosphate(13879-76-0)

Safety Data

• Hazardous Substances Data: 13879-76-0(Hazardous Substances Data)

Usage

Chemical Properties

Oil

Uses

Labelled 2,2-Dimethyl-1,3-dioxolane-4-methanol Dibenzyl Phosphate (D472665). Used in the preparation of inhibitors of phosphatidylinositol-specific phospholipase C and myo-Inositol 1,2,3-Trisphosphate (I666010).

Upstream product

• 202338-43-0 1,2-di-O-isopropylideneglycerophosphorochloridate 
• 100-51-6 benzyl alcohol 
• 538-37-4 dibenzyl phosphochloridate 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 17176-77-1 Dibenzyl phosphite 
• 990-91-0 dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate 
• 1623-08-1 phosphoric acid dibenzyl ester 
• 34832-91-2 1,2-O-isopropylideneglyceryl N,N,N'N,-tetraethylphosphorodiamidite 
• 67746-43-4 dibenzyl N,N-diethylphosphoramidite 
• 67746-41-2 dibenzyl 1,2-O-isopropylideneglycerol 3-phosphite 
• 123417-05-0 dibenzyl phosphorofluoridate 

Downstream Products

• 183999-21-5 Hexanoic acid 2-(bis-benzyloxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester 
• 901767-25-7 3-(bis(benzyloxy)phosphoryloxy)propane-1,2-diyl bis(3-ethylheptanoate) 
• 183999-20-4 dibenzyl 2,3-dihydroxypropyl phosphate 

Relevant articles and documents

Conformational study of the natural iron chelator myo-inositol 1,2,3-trisphosphate using restrained/flexible analogues and computational analysis

Myo-Inositol 1,2,3-trisphosphate [Ins(1,2,3)P3], a component in mammalian cells, possesses the correct chemical properties of an intracellular iron transit ligand. Here we have examined the conformation of the Ins(1,2,3)P3-Fe3+ complex. The synthesis and antioxidant properties of 4,6-carbonate-myo-inositol 1,2,3,5-tetrakisphosphate [4,6-carbonate Ins(1,2,3,5)P4], which is locked in the unstable penta-axial chair conformation and 1,2,3-trisphosphoglycerol, a flexible acyclic analogue of Ins(1,2,3)P3, are reported. 4,6-Carbonate Ins(1,2,3,5)P4 caused complete inhibition of iron-catalysed hydroxyl radical (HO?) formation at 100 μM, thereby resembling Ins(1,2,3)P3 and supporting a penta-axial chair binding conformation. In contrast, 1,2,3-trisphosphoglycerol was shown to have incomplete antioxidant properties. In support of experimental observations, we have applied high-level density functional calculations to the binding of Ins(1,2,3)P3 to iron. This study provides evidence that Fe3+ binds tightly to the less stable penta-axial conformation of Ins(1,2,3)P3 using terminal and bridging phosphate oxygens, thought to also contain a tightly bound water molecule or hydroxyl ligand in the complex.

Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus

Substrate analog inhibitors of Bacillus cereus phosphatidylinositol- specific phospholipase C (PI-PLC) were synthesized and screened for their suitability to map the active site region of the enzyme by protein crystallography. Analogs of the natural subst

A new approach to the synthesis of phosphatidic acids and their analogs

The synthesis of phosphatidic acids, their monoamides and dialkyl esters, and thiophosphatidic acids was realized on the basis of the amidophosphites of 1,2-diacylglycerols and 1,2-isopropylideneglycerol.