138867-57-9Relevant academic research and scientific papers
2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL (BINAP). A NEW ATROPISOMERIC BIS(TRIARYL)PHOSPHINE. SYNTHESIS AND ITS USE IN THE Rh(I)-CATALYZED ASYMMETRIC HYDROGENATION OF α-(ACYLAMINO)ACRYLIC ACIDS
Miyashita, A.,Takaya, H.,Souchi, T.,Noyori, R.
, p. 1245 - 1253 (1984)
Racemic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl has been synthesized from 2,2'-dihydroxy-1,1'-binaphthyl in two steps and resolved into optically pure (R)-(+) and (S)-(-) enantiomers by the use of (+)-di-μ-chlorobis dipalladium.This new axially dissymmetric bis(triaryl)phosphine serves as an excellent ligand for Rh(I)-catalyzed asymmetric hydrogenations of α-(acylamino)acrylic acids or esters.Factors controlling the enantioselectivity and mechanistic aspects are discussed on the basis of the 31P-NMR measurements.
