138871-56-4

Basic information

• Product Name: (2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER
• Synonyms: (2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER;L-1-BOC-O-TBDPS-PYROGLUTAMINOL;(S)-Tert-Butyl 2-(((Tert-Butyldiphenylsilyl)Oxy)Methyl)-5-Oxopyrrolidine-1-Carboxylate;(S)-Tert-Butyl 2-(((Tert-Butyldiphenylsilyl)Oxy)Methyl)-5-Oxopyrrolidine-1-Carboxylate(WXC03967)
• CAS NO: 138871-56-4
• Molecular Formula: C₂₆H₃₅NO₄Si
• Molecular Weight: 453.65
• Mol File: 138871-56-4.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(138871-56-4)
• EPA Substance Registry System: (2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(138871-56-4)

Safety Data

• Hazardous Substances Data: 138871-56-4(Hazardous Substances Data)

Usage

General Description

The chemical "(2S)-2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-5-oxo-1-pyrrolidinecarboxylate-1,1-dimethylethyl ester" is a complex compound with a pyrrolidinecarboxylate core and a siloxane substituent. It is a derivative of 1,1-dimethylethyl ester and contains a 5-oxo functional group. This chemical may have potential applications in pharmaceuticals, organic synthesis, or materials science. However, due to its complexity and specific structure, it should be handled and studied with caution and expertise.

Upstream product

• 81658-25-5 2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17342-08-4 (S)-Pyroglutaminol 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 185303-86-0 N-(tert-butoxycarbonyl)-6,7-O-isopropylidene-2,3-dideoxy-L-arabinoheptono-1,4-lactam 
• 141393-87-5 4-<(tert-butoxycarbonyl)amino>-6,7-O-isopropylidene-2,3,4-trideoxy-L-arabino-hept-2-enonic acid 1,4-lactam 
• 185303-87-1 tert-butyl (S)-2-formyl-5-oxopyrrolidine-1-carboxylate 
• 141293-28-9 N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 

Downstream Products

• 138871-68-8 [(S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-4-[1,3]dithian-2-yl-4-oxo-butyl]-carbamic acid tert-butyl ester 
• 138871-64-4 (S)-tert-butyl (1-((tert-butyldiphenylsilyl)oxy)-5-oxohexan-2-yl)carbamate 
• 1644276-84-5 tert-butyl (S,E)-2-[(tert-butyldiphenylsilyloxy)methyl]-5-(2-oxopentylidene)pyrrolidine-1-carboxylate 
• 1644276-83-4 tert-butyl (S)-1-(tert-butyldiphenylsilyloxy)-5-oxodec-6-yn-2-ylcarbamate 
• 1357356-26-3 (2S,5S)-1-(t-butyloxycarbonyl)-2-[(t-butyldiphenylsilyl)oxymethyl]-5-[2-(ethyloxycarbonyl)-(E)-ethenyl]pyrrolidine 
• 1203491-15-9 (2S,5S)-1-(tert-butyloxycarbonyl)-5-[(tert-butyldiphenylsilyl)oxymethyl]-2-[2-(methyloxycarbonyl)ethyl]pyrrolidine 
• 1357356-24-1 (2S,5S)-1-(t-butyloxycarbonyl)-2-[(t-butyldiphenylsilyl)oxymethyl]-5-[2-(benzylaminocarbonyl)ethyl]pyrrolidine 

Relevant articles and documents

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.

Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano- L -Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer

The synthesis, structural properties, and folding patterns of a series of L-proline methanologues represented by cis- and trans-4,5-methano-L-proline amides and their oligomers are reported as revealed by X-ray crystallography, circular dichroism measurements, and DFT calculations. We disclose the first example of a crystalline tetrameric proline congener to exhibit a polyproline II helical conformation. Experimental evidence of PPII-type helical arrangement (both in solution and in the solid state) of cis-4,5-methano-L-proline oligomers is supported by theoretical calculations reflecting the extent of n→π? stabilization of the trans-amide conformation.