1388803-04-0Relevant articles and documents
Transformations of diphenylphosphinothioic acid tertiary amides mediated by directed ortho metallation
El Hajjouji, Hajar,Belmonte, Eva,Garcia-Lopez, Jesus,Fernandez, Ignacio,Iglesias, Maria Jose,Roces, Laura,Garcia-Granda, Santiago,El Laghdach, Anas,Lopez Ortiz, Fernando
, p. 5647 - 5658 (2012/08/08)
ortho-Lithiation of N,N-diisopropyl-P,P-diphenylphosphinothioic amide using n-BuLi in the presence of TMEDA in diethyl ether followed by electrophilic trapping is described as an efficient method for the synthesis of ortho-functionalised derivatives in high yields. The structural modification of the phosphinothioic amide includes C-X (X = P, S, Si, Sn, I) and C-C bond forming reactions with a large variety of electrophiles. Additional applications based on functional group transformations are also reported. They include imine formation, desulfurization and Suzuki cross-coupling reactions on selected compounds.