138883-56-4Relevant academic research and scientific papers
Diastereoselective total synthesis of (+)-13-stemarene by fourth generation methods: A formal total synthesis of (+)-18-deoxystemarin
Leonelli, Francesca,Blesi, Federico,Dirito, Paolo,Trombetta, Andrea,Ceccacci, Francesca,La Bella, Angela,Migneco, Luisa M.,Marini Bettolo, Rinaldo
, p. 6871 - 6876 (2011)
The problem of constructing diastereoselectively the C/D ring system of stemarane diterpenes from a bicyclo[2.2.2]octane intermediate was solved resulting in very simple synthesis of (+)-13-stemarene 1. The obtaining of the latter represents also a formal synthesis of (+)-18-deoxystemarin 2. In the key step, the epimeric mixture 10, dissolved in toluene, was converted by the action of TsOH into (+)-stemar-13-en-15-one 28.
