138902-06-4Relevant articles and documents
Irreversible Deactivation of Human &β-Hexosaminidase A with the Alkylating Pseudodisaccharide (3,4,6/5)-6-(2-Acetamido-2-deoxy-&β-D-glucopyranosylthio)-3,4-epoxy-5-hydroxycyclohexene
Kuhn, Cai-Steffen,Lehmann, Jochen,Sandhoff, Konrad
, p. 407 - 410 (2007/10/02)
(3,4,6/5)-6-(2-Acetamido-2-deoxy-β-D-glucopyranosylthio)-3,4-epoxy-5-hydroxycyclohexene (8b) has been synthesised and found to deactivate irreversibly human β-D-hexosaminidase from lysosomes.Deactivation did not take place in the presence of the competiti