138914-88-2

Upstream product

• 147833-04-3 (1α,3β,5Z,7E)-1,3-bis(t-butyldimethylsilyloxy)-24-oxa-9,10-secocholesta-5,7,10(19)-triene 
• 55812-82-3 (1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol 
• 147833-09-8 (8β)-de-A,B-8-methoxymethyloxy-23,24-dinorcholan-23-yl 4-toluenesulfonate 
• 147833-05-4 (1S,4S,6R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,3aS,7aR)-1-((R)-3-isopropoxy-1-methyl-propyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-1,3,4,5,6,7-hexahydro-benzo[c]thiophene 2,2-dioxide 
• 147833-02-1 (1S,3R,5E,7E,22ξ)-1,3-bis-(t-butyldimethylsilyloxy)-22-methylselenyl-24-oxa-9,10-secocholesta-5,7,10(19)-triene 
• 147833-04-3 (1S,3R,5E,7E)-1,3-bis-(t-butyldimethylsilyloxy)-24-oxa-9,10-secocholesta-5,7,10⁽¹⁹⁾-triene 
• 147832-97-1 (4S,6R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,3aS,7aR)-1-((S)-3-isopropoxy-1-methyl-2-methylselanyl-propyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-1,3,4,5,6,7-hexahydro-benzo[c]thiophene 2,2-dioxide 
• 138914-94-0 (1α,3β)-1,3-bis(t-butyldimethylsilyloxy)-24-oxa-9,10-secocholesta-5(10),8-dien-6-yne 
• 138937-78-7 (3R,3aR,7aR)-7-{(Z)-2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enyl]-vinyl}-3-((R)-3-isopropoxy-1-methyl-propyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene 
• 138914-92-8 de-A,B-24-oxacholest-8-en-8-yl trifluoromethanesulfonate 
• 138914-89-3 (8β)-de-A,B-8-methoxymethyloxy-24-norcholane-23-nitrile 
• 138914-90-6 (8β)-de-A,B-8-methoxymethyloxy-24-oxacholestane 
• 147833-10-1 (8β)-de-A,B-8-methoxymethyloxy-24-norcholane-23-ol 
• 147833-08-7 (8β)-de-A,B-8-methoxymethyloxy-23,24-dinorcholan-22-ol 

Downstream Products

• 71204-89-2 1α,3β-dihydroxy-9,10-seco-24-norchola-5,7-10(19)-trien-23-oic acid 
• 97903-37-2 24,25,26,27-tetranor-1,23-(OH)2D₃ 

Relevant academic research and scientific papers

Synthesis of 24-oxavitamin D3 and 1α-hydroxy-24-oxavitamin D3

Coupling of the CD fragment, ketone 6 (obtained by partial synthesis from vitamin D2), either directly (Horner-Wittig route) or via the derived enol triflate (dienyne route) with the appropriate A-ring fragment, phosphine oxide anion 7 or enyne

The Seleno-acetal Route to 1α-Hydroxy-vitamin D Analogues: Synthesis of 24-Oxa-1α-hydroxy-vitamin D3, A Useful Vitamin D Metabolism Probe

Alkylation of the lithio-demethylseleno-derivative of seleno-acetal 11 with chloromethyl isopropyl ether is the key reaction in the synthesis of the 24-oxa analogue (M