138915-39-6

Upstream product

• 88496-70-2 methyl (R)-4-chloro-3-hydroxybutyrate 
• 98-59-9 p-toluenesulfonyl chloride 
• 125605-10-9 (3R)-4-chloro-1,3-butanediol 

Downstream Products

• 100937-75-5 3-(R)-hydroxytetrahydrothiophene 

Relevant academic research and scientific papers

Process for preparing 3-Hydroxythiolane

A process for preparing 3-hydroxythiolane which is characterized by reacting a compound of the following formula, ???wherein X is a halogen atom, and R2 is a substituted or unsubstituted alkyl group, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aryl group, with a metal sulfide.

Process for preparing optically active 3-hydroxypyrrolidine derivatives

A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): STR1 wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): STR2 wherein * is as defined above; R1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II): wherein Q is as defined above, is disclosed. The starting compound (I) is easily available through chemical synthesis. Any complicated procedure or use of an expensive reagent is not required.