1389338-67-3Relevant academic research and scientific papers
Ring-closing metathesis based total synthesis of ciliatamides A and B and their structural confirmation
Avula, Krishnakumari,Mohapatra, Debendra K.
, p. 1715 - 1717 (2016)
Protecting group dependant ring-closing metathesis based approach to the total synthesis of the revised structures of ciliatamides A and B has been described. The current synthetic strategy utilizes the amino acid as starting material to introduce both the stereogenic centers. However, usage of non-racemizing reagents (EDC·HCl, HATU/NMM); for amide coupling and Grubbs' second generation catalyst for caprolactam ring synthesis makes the present approach more convenient to get the correct conclusion on absolute stereochemistry. Thus, on the basis of similar optical rotation values with the Lindsley's reported data, this synthesis further supported for the actual stereochemistry of both ciliatamides A and B is (R,R).
Synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis
Fuhshuku, Ken-Ichi,Asano, Yasuhisa
experimental part, p. 6651 - 6655 (2012/08/29)
The synthesis of optically active medium-sized α-aminolactams via ring-closing metathesis is described. The amidation of optically active N-Boc-allylglycine derivatives with N-protected alkenylamine, and ring-closing metathesis resulted in the formation o
