1389397-40-3Relevant academic research and scientific papers
Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease
Sheng, X. Christopher,Appleby, Todd,Butler, Thomas,Cai, Ruby,Chen, Xiaowu,Cho, Aesop,Clarke, Michael O.,Cottell, Jeromy,Delaney IV, William E.,Doerffler, Edward,Link, John,Ji, Mingzhe,Pakdaman, Rowchanak,Pyun, Hyung-Jung,Wu, Qiaoyin,Xu, Jie,Kim, Choung U.
, p. 2629 - 2634 (2012/05/05)
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monke
