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NAZUMAMIDE A is a cyclic tetrapeptide natural product isolated from the fermentation broth of Streptomyces sp., featuring a rare 3-hydroxy-2,4,6-trimethylheptanoic acid (HTA) moiety. NAZUMAMIDE A has shown inhibitory activity against acetylcholinesterase, an enzyme associated with neurodegenerative disorders like Alzheimer's disease, and has also displayed moderate antibacterial activity against various Gram-positive and Gram-negative bacterial strains. Its distinctive chemical structure and biological potential render NAZUMAMIDE A a promising candidate for further research as a therapeutic agent.

138949-86-7

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138949-86-7 Usage

Uses

Used in Pharmaceutical Industry:
NAZUMAMIDE A is used as a potential therapeutic agent for neurodegenerative disorders such as Alzheimer's disease, due to its inhibitory activity against the acetylcholinesterase enzyme, which plays a role in the progression of these conditions.
Used in Antibacterial Applications:
In the field of antimicrobial research, NAZUMAMIDE A is utilized for its demonstrated moderate antibacterial activity against a range of Gram-positive and Gram-negative bacterial strains, indicating its potential as a new class of antimicrobial agents.
Used in Drug Development Research:
NAZUMAMIDE A serves as a subject of interest in drug development research due to its unique chemical structure and the biological activities it has exhibited, which may lead to the discovery of new therapeutic agents with novel mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 138949-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,9,4 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 138949-86:
(8*1)+(7*3)+(6*8)+(5*9)+(4*4)+(3*9)+(2*8)+(1*6)=187
187 % 10 = 7
So 138949-86-7 is a valid CAS Registry Number.

138949-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name NAZUMAMIDE A

1.2 Other means of identification

Product number -
Other names 2,5-DIHYDROXY-BZ-ARG-PRO-ILE-ABU

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138949-86-7 SDS

138949-86-7Downstream Products

138949-86-7Relevant academic research and scientific papers

Synthesis of Nazumamide A, a Thrombin-Inhibitory Linear Tetrapeptide, from a Marine Sponge, Theonella sp.

Hayashi, Kyoko,Hamada, Yasumasa,Shioiri, Takayuki

, p. 5075 - 5076 (2007/10/02)

Nazumamide A (1), a thrombin-inhibitory linear tetrapeptide of marine origin, was efficiently constructed using diethyl phosphorocyanidate (DEPC) as a coupling reagent.

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