138952-03-1

Basic information

• Product Name: 2,2-bis(4-methylphenyl)-4-pentenoic acid
• Synonyms: 2,2-bis(4-methylphenyl)-4-pentenoic acid
• CAS NO: 138952-03-1
• Molecular Weight: 280.367
• Mol File: 138952-03-1.mol

Chemical Properties

• CAS DataBase Reference: 2,2-bis(4-methylphenyl)-4-pentenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-bis(4-methylphenyl)-4-pentenoic acid(138952-03-1)
• EPA Substance Registry System: 2,2-bis(4-methylphenyl)-4-pentenoic acid(138952-03-1)

Safety Data

• Hazardous Substances Data: 138952-03-1(Hazardous Substances Data)

Upstream product

• 20809-78-3 bis-(4-methylphenyl)acetic acid 
• 106-95-6 allyl bromide 

Downstream Products

• 158182-71-9 2,2-Di-p-tolyl-pent-4-enoyl chloride 
• 153958-45-3 2,3-bis(4-methylphenyl)-2-cyclopenten-1-one 

Relevant articles and documents

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An iridium/dppf complex efficiently catalyzed the oxidative cyclization of N sulfonyl alkenyl amides and alkenoic acids. Electron deficiena?t alkenes were effective as sacrificial hydrogen acceptors. High selectivity of the oxidative cyclization over the

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As part of our search for new agents for the treatment of overactive detrusor, 2,3- and 3,4-diphenylcyclopentylamines (3), 2,3-diphenyl-2-cyclopentenylamines (4), and related compounds (5 and 18) were synthesized and evaluated for inhibitory activity (i.v.) against urinary bladder rhythmic contraction in rats. Among them, some compounds involving N-tert-butyl-2,3-diphenyl-2-cyclopentenylamine (4b) exhibited inhibitory activity against bladder contraction superior to that of terodiline (2). Mydriatic activity (i.v.) of compound 4b in rats, an index of its side effects due to antimuscarinic activity, was found to be relatively weak in comparison with its inhibitory activity against bladder contraction. The pharmacological profile of 4b was examined in comparisen with that of terodiline. Most of the objective amines (3, 4, 5) were synthesized by preparation of Schiff bases from the corresponding cyclic ketones (6, 7, 8) and amines in the presence of TiCl4 in CH2Cl2 and subsequent reduction with NaBH4 in the presence of MeOH in one pot (method A).

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