138971-91-2Relevant academic research and scientific papers
REACTIONS OF NITROGEN NUCLEOPHILES WITH 1-BROMOALLENES: REGIOSELECTIVE SYNTHESIS OF PROPARGYLAMINES
Geri, Roberto,Polizzi, Carmela,Lardicci, Luciano,Caporusso, Anna Maria
, p. 241 - 248 (2007/10/02)
The results of a study on the reactivity of 3-alkyl- and 3,3-dialkyl-1-bromo-1,2-dienes 2 towards nitrogen nucleophiles, such as aqueous ammonia, lithium amide, aliphatic and aromatic amines allowed us to propose new methods for the synthesis of propargylamines, 1, with an available acetylenic hydrogen.The regio- and the stereoselectivity of these reactions are examined and possible mechanisms are discussed.
Copper Catalyzed Aminolysis of Bromoallenes as a New Efficient Route to Propargylamines
Caporusso, Anna Maria,Geri, Roberto,Polizzi, Carmela,Lardicci, Luciano
, p. 7471 - 7472 (2007/10/02)
An efficient procedure of general applicability for the synthesis of secondary and tertiary propargylamines by copper mediated aminolysis of 1-bromo-1,2-dienes is described.Key Words: propargylamines; bromoallenes; aminolysis; regioselectivity; Cu promote
