13899-60-0Relevant academic research and scientific papers
Facile entry to the tetracyclic 5-7-6-3 tigliane ring system
Ovaska, Timo V.,Reisman, Sarah E.,Flynn, Meghan A.
, p. 115 - 117 (2001)
(equation presented) A tandem anionic 5-exo-dig cyclization/Claisen rearrangement sequence was used to effect a facile, "one-pot" conversion of an appropriately substituted 4-alkyn-1-ol to the tetracyclic carbon core structure of phorbol. The synthesis was conducted using readily available nonracemic starting materials to provide the target structure as a single enantiomer in high chemical yield.
