138990-99-5

Upstream product

• 106-49-0 p-toluidine 
• 17422-74-1 3-Formylchromone 

Downstream Products

• 65160-35-2 2-Methylphenyl-10H-<1>benzopyrano<3,2-c>pyridine-3,10(2H)-dione 
• 143947-51-7 3-(N-Benzoylamino)-3-methyl-4-(4-oxobenzopyran-3-yl)-N-p-tolylazetidin-2-one 
• 143947-57-3 3-(N-Phenylacetylamino)-4-(4-oxobenzopyran-3-yl)-3-methyl-N-p-tolylazetidin-2-one 
• 143947-52-8 3-(N-p-Anisoylamino)-3-methyl-4-(4-oxobenzopyran-3-yl)-N-p-tolylazetidin-2-one 

Relevant academic research and scientific papers

Synthesis of 3-aminomethylidenechroman-2-carboxamides by a Sequential One-pot Three Component Reaction and by Post-Passerini Condensation Modification

3-Arylaminomethylidenechroman-2-carboxamide has been synthesized by a one-pot three component reaction among 3-formylchromone, aromatic amine, and cyclohexyl isocyanide. 3-(N-alkylsubstitued/unsubstituted)aminomethylidenechroman-2-carboxamides were synthesized by heating Passerini products derived from chromone-3-carbaldehyde with different aliphatic primary amines. The products obtained from the reactions of aliphatic primary amines readily form chromeno[2,3-c]pyrrole when heated in acetic acid. Bischromanones have also been synthesized using this methodology.

Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors

3-Formylchromone (1), 3-methyl-7-hydroxychromone (2) and Schiff bases of 3-formylchromone 3-19 have been synthesized and their anti-thymidine phosphorylase inhibitory activity was evaluated. Compounds 1-19 showed a varying degree of thymidine phosphorylase inhibition with IC50 values 19.77 ± 3.25 to 480.21 ± 2.34 μM. Their activity was compared with the standard 7-deazaxanthine (IC50 = 39.28 ± 0.76 μM). Compound 12 showed an excellent thymidine phosphorylase inhibitory activity with an IC50 value of 19.77 ± 3.25 μM, better than the standard. Compound 4 also showed an excellent inhibitory activity (IC50 = 40.29 ± 4.56 μM). The parent 3-formylchromone (1) and 3-methyl-7-hydroxychromone (2) were found to be inactive. The structures of the compounds were elucidated by using spectroscopic techniques, including 1H NMR, EI MS, IR, UV and elemental analysis.

Indium triflate: A new catalyst for (4 + 2)-cycloaddition of chromone Schiff's bases

Indium triflate was introduced as a new catalyst for (4+2)-cycloaddition of chromone Schiff's bases. 3,4-Dihydro-2H-pyran reacted with a variety of chromone Schiff's bases in the presence of indium and scandium triflates at ambient temperature and pressur

Studies on Chromone Derivatives. A Direct and Efficient One-pot Synthesis of 4-Chromone-linked 3-(N-Acylamino)azetidin-2-ones from Imines and N-Acylalanine

Chlorosulfonylmethylene(dimethyl)ammonium chloride 1 is found to be an efficient cyclodehydrating agent for the one-pot synthesis of various novel chromone-linked azetidin-2-ones 6 via cycloaddition reactions of 3-(arylaminomethyl)chromones 5 with in situ