139006-77-2

Basic information

• Product Name: Eupomatilone 3
• CAS NO: 139006-77-2
• Molecular Weight: 430.455
• Mol File: 139006-77-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Eupomatilone 3(CAS DataBase Reference)
• NIST Chemistry Reference: Eupomatilone 3(139006-77-2)
• EPA Substance Registry System: Eupomatilone 3(139006-77-2)

Safety Data

• Hazardous Substances Data: 139006-77-2(Hazardous Substances Data)

Upstream product

• 81474-47-7 methyl-6-bromo-7-methoxybenzo [d] [1, 3] dioxole-5-carboxylate 
• 870094-80-7 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 870094-81-8 [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol 
• 870094-82-9 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde 
• 870094-83-0 5-[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]-4-methyl-5H-furan-2-one 
• 74-88-4 methyl iodide 

Relevant articles and documents

Divergent Total Syntheses of Gymnothelignan N, Beilschmin A, and Eupomatilones 1, 3, 4, and 7

A seven-step asymmetric total synthesis of gymnothelignan N is detailed in the current report. The approach is based on an early-stage one-carbon homologative lactonization reaction, which we recently revisited and modified to construct the core γ-butyrolactone motif with the requisite β,γ-vicinal stereogenic centers. By design, the utilization of the same chiral γ-butyrolactone intermediate permitted the rapid and effective divergent assembly of optically active eupomatilones 1, 3, 4, and 7 in five or six steps from commercially available materials. This represents one of the shortest and highest-yielding syntheses reported to date.