139022-25-6Relevant articles and documents
PROCESS FOR PREPARATION OF SAVOLITINIB AND ITS INTERMEDIATES
-
Page/Page column 30, (2021/11/20)
The present application relates to a process for preparation of chiral amine fragment (IV) of savolitinib. The present application also relates to a process for preparation of savolitinib using the chiral amine (IV), as prepared by the process of the present application. The present application also discloses new intermediates useful for the synthesis of savolitinib. The present application further relates to crystalline forms of savolitinib, namely AA1, formic acid solvate and AA2. The present application also relates to amorphous solid dispersion of savolitinib.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
-
Paragraph 0287-0289, (2018/04/17)
The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.
AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES
-
Page/Page column 143, (2013/09/12)
Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
