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139022-27-8

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139022-27-8 Usage

Description

Imidazo[1,2-a]pyridine, 6-fluoro(9CI) is a heterocyclic aromatic chemical compound characterized by the molecular formula C8H6FN. It features a unique structure that incorporates both nitrogen and fluorine atoms, which may contribute to its potential applications in various fields.

Uses

Used in Medicinal Chemistry:
Imidazo[1,2-a]pyridine, 6-fluoro(9CI) is used as a building block or intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic properties.
Used in Agriculture:
In the agricultural industry, Imidazo[1,2-a]pyridine, 6-fluoro(9CI) may be utilized as a component in the development of agrochemicals, such as pesticides or herbicides, due to its chemical properties.
Used in Materials Science:
Imidazo[1,2-a]pyridine, 6-fluoro(9CI) could be employed in the field of materials science for the design and synthesis of new materials with specific properties, such as electronic, optical, or mechanical characteristics.
Used as a Research Tool in Chemical Biology:
Imidazo[1,2-a]pyridine, 6-fluoro(9CI) may also serve as a valuable research tool in chemical biology, where it can be used to study biological processes or to develop new probes for investigating molecular interactions.

Check Digit Verification of cas no

The CAS Registry Mumber 139022-27-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,0,2 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 139022-27:
(8*1)+(7*3)+(6*9)+(5*0)+(4*2)+(3*2)+(2*2)+(1*7)=108
108 % 10 = 8
So 139022-27-8 is a valid CAS Registry Number.

139022-27-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-fluoroimidazo[1,2-a]pyridine

1.2 Other means of identification

Product number -
Other names 6-fluoro-imidazo[1,2-a]pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139022-27-8 SDS

139022-27-8Relevant articles and documents

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase

Juillet, Charlotte,Ermolenko, Ludmila,Boyarskaya, Dina,Baratte, Blandine,Josselin, Béatrice,Nedev, Hristo,Bach, Stéphane,Iorga, Bogdan I.,Bignon, Jér?me,Ruchaud, Sandrine,Al-Mourabit, Ali

, p. 1197 - 1219 (2021/02/05)

Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into the potent CJ2-150 (37). Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biologically oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 (37) showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Molecular docking identified a probable binding mode in the allosteric site "F"and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action.

Heteroaryl imidazolone derivatives as jak inhibitors

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Page/Page column 46, (2012/01/06)

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS

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Page/Page column 100, (2011/07/09)

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

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