139052-00-9

Basic information

• Product Name: (R)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid
• Synonyms: (R)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid
• CAS NO: 139052-00-9
• Molecular Weight: 249.266
• Mol File: 139052-00-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid(139052-00-9)
• EPA Substance Registry System: (R)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid(139052-00-9)

Safety Data

• Hazardous Substances Data: 139052-00-9(Hazardous Substances Data)

Upstream product

• 103-84-4 Acetanilid 
• 616-02-4 citraconic acid anhydride 
• 139052-03-2 3-(p-Acetamidobenzoyl)-crotonsaeure 

Downstream Products

• 134052-12-3 2-{1,1-Dimethyl-2-[4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione 
• 134000-06-9 (R)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one 
• 36725-28-7 OR-1855 
• 139052-02-1 OR-1896 

Relevant articles and documents

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).