139060-06-3Relevant articles and documents
Synthesis and cytotoxic activity of a series of diacetylenic compounds related to falcarindiol
Setzer,Gu,Wells,Setzer,Moriarity
, p. 1776 - 1777 (2000)
The synthesis of a series of diacetylenic compounds related to the natural product falcarindiol has been carried out. Unsymmetrical diacetylenes were prepared by a modification of the Cadiot-Chodkiewicz coupling reaction, while a Glaser coupling was used to prepare symmetrical diacetylenes. These compounds have been tested for in vitro cytotoxic activity against Hep-G2, and H-4-II-E cell lines. Diacetylenes with additional unsaturation at C-1, 2, appended with hydroxyl groups at C-3 and C-8, or with long hydrophobic chains, exhibited IC50 values in the micromolar range.
Cationic Amphiphiles Bearing a Diacetylenic Function in the Headgroup: Aggregative Properties and Polymerization
Mauceri, Alessandro,Giansanti, Luisa,Capitani, Donatella,Sobolev, Anatoly,Galantini, Luciano,Bassetti, Mauro,Nemi, Maria Grazia,Gradella Villalva, Denise,Battista, Sara,Mancini, Giovanna
, p. 12168 - 12178 (2020)
In the wide panorama of diacetylenic lipids, the photoresponsive conjugated 1,3-diyne function is usually encased into the hydrocarbon chain of the amphiphile at a variable distance from the headgroup. Therefore, the polydiacetylene network obtained by polymerization upon UV irradiation of the corresponding liposomes, exploited as sensing function, is embedded in the hydrophobic region of liposomes. Structurally related cationic diacetylenic amphiphiles featuring the conjugated triple bonds proximate to charged nitrogen were synthesized and evaluated in their ability to polymerize under aggregative conditions. The occurrence of polymerization only in certain aggregating conditions was rationalized by nuclear magnetic resonance (NMR) and Langmuir trough experiments.
New irreversible thermochromic polydiacetylenes
Rougeau, Laurent,Picq, Dominique,Rastello, Marie,Frantz, Yves
, p. 9430 - 9436 (2008/12/22)
New diacetylenic compounds are described. These compounds are unfunctionalised, monoalcohols, diols or monoesters and present irreversible thermochromic behaviour. When heated, these diynes change colour from blue to red in temperature ranging between -50 and +75 °C depending on chain lengths. A relationship between the number of atoms and the thermochromism temperature has been highlighted. Moreover, a mechanism of this thermochromic phenomenon is demonstrated based on Raman spectroscopy, ESR and solid NMR.
