1390641-05-0

Basic information

• Product Name: C₁₇H₁₆N₄O₂S
• CAS NO: 1390641-05-0
• Molecular Weight: 340.406
• Mol File: 1390641-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆N₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆N₄O₂S(1390641-05-0)
• EPA Substance Registry System: C₁₇H₁₆N₄O₂S(1390641-05-0)

Safety Data

• Hazardous Substances Data: 1390641-05-0(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 65001-21-0 5-bromopyridine-3-sulphonyl chloride 
• 1086064-93-8 C₁₂H₁₁BrN₂O₂S 
• 84249-14-9 2-amino-4-bromopyridine 

Downstream Products

• 1204519-66-3 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide 
• 1390641-16-3 C₂₁H₂₁N₅O₄S₂ 

Relevant articles and documents

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl) pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease

Herein, we disclose the discovery of a series of 7-substituted triazolopyridines which culminated in the identification of 14 (CZC24758), a potent, orally bioavailable small-molecule inhibitor of PI3Kγ, an attractive drug target for inflammatory and autoimmune disorders. Compound 14 has excellent selectivity across the kinome, demonstrates good potency in cell based assays and furthermore exhibits in vivo efficacy in a collagen induced arthritis model in mouse after oral dosing.