13908-41-3

Basic information

• Product Name: 1-(2-chloroethyl)-3-(3-nitrophenyl)urea
• CAS NO: 13908-41-3
• Molecular Formula: C₉H₁₀ClN₃O₃
• Molecular Weight: 243.647
• Mol File: 13908-41-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Density: 1.424g/cm³
• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 1-(2-chloroethyl)-3-(3-nitrophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-(3-nitrophenyl)urea(13908-41-3)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-(3-nitrophenyl)urea(13908-41-3)

Safety Data

• Hazardous Substances Data: 13908-41-3(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-3-(3-nitrophenyl)urea, also known as chloroethyl nitrourea, is a chemical compound that is used as an herbicide. It is a white crystalline solid with the molecular formula C8H8ClN3O3 and a molecular weight of 229.62 g/mol. 1-(2-chloroethyl)-3-(3-nitrophenyl)urea inhibits photosynthesis in plants and hence is used as a selective herbicide for controlling grassy and broad-leafed weeds in crops like soybeans, corn, and cotton. It works by interfering with the growth process of the weeds and causing them to die. However, it should be used with caution as it can be harmful to aquatic organisms and may cause skin and eye irritation in humans.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 1173087-44-9 C₉H₁₂ClN₃O 
• 13991-77-0 C₉H₉ClN₄O₄ 

Relevant articles and documents

Synthesis and activity evaluation of phenylurea derivatives as potent antitumor agents

We have discovered several tubulin-active compounds in our previous studies. In the establishment of a compound library of small molecule weight tubulin ligands, 14 new N-3-haloacylaminophenyl-N′-(alkyl/aryl) urea analogs were designed and synthesized. The structure-activity relationship (SAR) analysis revealed that (i) the order of anticancer potency for the 3-haloacylamino chain was following -CH2Br > -CHBrCH3; (ii) the N′-substituent moiety was not essential for the anticancer activity, and a proper alkyl substitution might enhance the anticancer activity. Among these analogs, the compounds 16j bearing bromoacetyl at the N′-end exhibited a potent activity against eight human tumor cell lines, including CEM (leukemia), Daudi (lymphoma), MCF-7 (breast cancer), Bel-7402 (hepatoma), DU-145 (prostate cancer), DND-1A (melanoma), LOVO (colon cancer) and MIA Paca (pancreatic cancer), with the IC50 values between 0.38 and 4.07 μM. Interestingly, compound 16j killed cancer cells with a mechanism independent of the tubulin-based mechanism, indicating a significant change of the action mode after the structure modification.