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13909-14-3

1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea, commonly known as CCNU, is a nitrosourea derivative characterized by its potent cytotoxic and antineoplastic properties. It is recognized for its ability to alkylate DNA, thereby disrupting the replication and transcription processes, which ultimately results in cell death. CCNU is notable for its oral administration feasibility, good absorption, and long half-life, which allows for less frequent dosing. However, its use is accompanied by potential adverse effects such as myelosuppression, gastrointestinal toxicity, and possible long-term impacts on the liver and kidneys, necessitating close monitoring and dose adjustments.

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  • 13909-14-3 Structure

  • Basic information

    1. Product Name: 1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea
    2. Synonyms: 1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea
    3. CAS NO:13909-14-3
    4. Molecular Formula: C15H28ClN3O2
    5. Molecular Weight: 317.91
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 13909-14-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.1674 (rough estimate)
    6. Refractive Index: 1.5200 (estimate)
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea(13909-14-3)
    11. EPA Substance Registry System: 1-(2-Chloroethyl)-3-cyclododecyl-1-nitrosourea(13909-14-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 13909-14-3(Hazardous Substances Data)

13909-14-3 Usage

Uses

Used in Oncology:
CCNU is utilized as a chemotherapeutic agent for the treatment of specific brain tumors, Hodgkin's disease, and multiple myeloma. Its application is grounded in its ability to interfere with the DNA of cancer cells, leading to cell death and thereby aiding in the management and treatment of these conditions.
Used in Pharmaceutical Research:
In the realm of pharmaceuticals, CCNU serves as a subject of interest for research and development. Its unique mechanism of action and potential for oral administration make it a valuable compound for exploring new therapeutic strategies and drug delivery systems to enhance its efficacy and safety profile.
Used in Drug Delivery Systems:
Similar to gallotannin, CCNU can also benefit from advancements in drug delivery systems. These systems aim to improve the bioavailability, targeting, and therapeutic outcomes of CCNU while reducing its systemic side effects. Various organic and metallic nanoparticles, as well as other innovative carriers, are being investigated for their potential to enhance the delivery and efficacy of CCNU in cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 13909-14-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13909-14:
(7*1)+(6*3)+(5*9)+(4*0)+(3*9)+(2*1)+(1*4)=103
103 % 10 = 3
So 13909-14-3 is a valid CAS Registry Number.

13909-14-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-chloroethyl)-3-cyclododecyl-1-nitrosourea

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13909-14-3 SDS

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