1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea, commonly known as lomustine, is a chemotherapy drug that belongs to the nitrosourea alkylating agents class. It is characterized by its ability to cross the blood-brain barrier and interfere with the DNA replication process in cancer cells, leading to their destruction. Lomustine is used in the treatment of specific types of brain tumors, lung cancer, and Hodgkin's disease.
13909-28-9
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Basic information
- Product Name: 1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea
- Synonyms: 1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea
- CAS NO:13909-28-9
- Molecular Formula: C12H15ClN4O3
- Molecular Weight: 298.7255
- EINECS: N/A
- Product Categories: N/A
- Mol File: 13909-28-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- Appearance: /
- Density: 1.31g/cm3
- Refractive Index: 1.582
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea(CAS DataBase Reference)
- NIST Chemistry Reference: 1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea(13909-28-9)
- EPA Substance Registry System: 1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea(13909-28-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 13909-28-9(Hazardous Substances Data)
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13909-28-9 Usage
Uses
Used in Oncology:Lomustine is used as a chemotherapy agent for the treatment of brain tumors, lung cancer, and Hodgkin's disease. It works by disrupting the DNA replication process in cancer cells, which ultimately results in their destruction. Its ability to cross the blood-brain barrier makes it particularly effective in treating brain tumors.
Used in Anticancer Drug Development:
Lomustine serves as a model for the development of new anticancer drugs, particularly those targeting brain tumors and other solid malignancies. Its mechanism of action as an alkylating agent provides insights into the design of novel compounds with improved efficacy and reduced side effects.
Used in Research:
Lomustine is utilized in research settings to study the effects of alkylating agents on cancer cells and to investigate the mechanisms underlying their cytotoxicity. This research can contribute to the development of more targeted and less toxic cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 13909-28-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,0 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.Calculate Digit Verification of CAS Registry Number 13909-28:
(7*1)+(6*3)+(5*9)+(4*0)+(3*9)+(2*2)+(1*8)=109
109 % 10 = 9
So 13909-28-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H15ClN4O3/c1-16(2)11(18)9-3-5-10(6-4-9)14-12(19)17(15-20)8-7-13/h3-6H,7-8H2,1-2H3,(H,14,19)
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1-(2-Chloroethyl)-3-[p-(dimethylcarbamoyl)phenyl]-3-nitrosourea
